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Zhang Hong, an academician of the Chinese Academy of Sciences and researcher at the Institute of Biophysics, won the Life Sciences Award of the 2026 Future Science Prize. Based on research on Caenorhabditis elegans, his team established a genetic screening system for autophagy in multicellular organisms and revealed the key mechanism by which local calcium signals on the endoplasmic reticulum regulate the initiation of autophagy. Regarding the current technical bottlenecks in the field of autophagy, such as the lack of biomarkers, inability to precisely regulate, and selective removal of substrates, Zhang Hong pointed out that artificial intelligence has limited role at this stage when the basic mechanisms are not fully understood. He emphasized the need to optimize the evaluation system constrained by journal impact factors, return to peer review, foster original innovation, be vigilant against the harms of “resource-based scientific research,” and call for the establishment of a scientific and technological evaluation system, adhering to an original research approach, and maintaining determination in facing the pressures faced by young researchers.
中国科学院院士、生物物理研究所研究员张宏荣获 2026 未来科学大奖生命科学奖。其团队基于秀丽隐杆线虫研究，建立了多细胞生物自噬遗传筛选体系，揭示了内质网表面局部钙信号调控自噬起始的关键机制。张宏指出，当前自噬领域面临缺乏生物标志物、无法精准调控及选择性清除底物等技术瓶颈，且人工智能在基础机制未完全厘清阶段作用有限。他强调需优化受期刊影响因子约束的评价体系，回归小同行评审以催生原始创新，并警惕“资源型科研”危害。张宏认为科学是动态探索过程而非绝对真理，呼吁建立科学科技评价体系，坚持走原创研究路线，保持定力应对青年科研人员压力。