对抗多重耐药菌肽分子有新策略
中国医学科学院医学生物学研究所张治业团队设计出结构简易的分支树状抗菌分子,为新型抗菌药物研发提供新思路。该分子在线性九肽基础上增设七肽分支并接入月桂酸,实现自我组装与稳定性提升。实验证实,这款双分支分子对多重耐药细菌具备强效广谱杀灭能力,在细胞与动物实验中展现良好生物安全性与治疗效果。其靶向破坏细菌细胞膜、干扰内部生理活动,并能清除生物膜及休眠细菌,不易催生耐药性,适用于慢性反复感染治疗。该成果规避了传统化学修饰合成复杂、成本高的短板,相关应用已取得发明专利授权。
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On September 8, 2026, the Technology Daily reported new developments in addressing multidrug-resistant bacteria. Researchers developed an intervention strategy based on peptide molecules aimed at addressing the growing problem of antibiotic resistance. This strategy involves designing specific peptide molecular structures to bypass bacterial defense mechanisms or inhibit their key functions, thereby restoring the effectiveness of existing antibiotics or providing new treatment options. This new strategy offers a potential solution for overcoming infections caused by multidrug-resistant bacteria, marking an important breakthrough in the fight against resistant bacteria.
中国医学科学院医学生物学研究所张治业团队设计出结构简易的分支树状抗菌分子,为新型抗菌药物研发提供新思路。该分子在线性九肽基础上增设七肽分支并接入月桂酸,实现自我组装与稳定性提升。实验证实,这款双分支分子对多重耐药细菌具备强效广谱杀灭能力,在细胞与动物实验中展现良好生物安全性与治疗效果。其靶向破坏细菌细胞膜、干扰内部生理活动,并能清除生物膜及休眠细菌,不易催生耐药性,适用于慢性反复感染治疗。该成果规避了传统化学修饰合成复杂、成本高的短板,相关应用已取得发明专利授权。